Estimates by David N. Osser, M.D. from analysis of the evidence, February 25, 2002. Estimates assume use of full antipsychotic doses.
| Item | Typical AD's | Clozapine | Risperidone | Olanzapine | Quetiapine | Ziprasidone |
|---|---|---|---|---|---|---|
| EPS | some - +++ | 0 | + ( less if <4mg) | 0-+ (if <10mg) | 0 | 0 - + |
| Tardive Dyskinesia | ++ - +++ | 0 - rare | rare | rare | rare | rare |
| Seizures | rare - 0.3% | 2-10% | ~0.3% | ~0.9% | ~0.8% | ~0.4% |
| Sedation | some - +++ | +++ | + | ++ | ++ | 0-+ |
| Orthostasis | some - +++ | +++ | ++ | + | +++ | + - ++ |
| Cardiac Conduction | + - +++ | + - ++ | + | + | + - ++ | ++ |
| Increased LFT's | some - ++ | ++ | 0 - + | ++ | ++ | 0 - + |
| Anticholinergic | some - +++ | +++ | 0 | 0 - + | 0 | 0 |
| Agranulocytosis | ~1 in 50,000 | 4 in 1000 | ~ 1 in 50,000 | ~1 in 50,000 | ~1 in 50,000 | ~1 in 50,000 |
| Prolactin Elevation | ++ - +++ | transient | +++ | 0 - + | 0 | 0 - + |
| Weight Gain | some - ++ | 12lbs. avg./10wks | 4 lbs. avg./ 6wks | 12lbs. avg./12wks | 6lbs. avg./6wks | 0 |
| Focal Cataracts | 0? | 0? | 0? | 0? | some risk | 0? |
| Metabolized by CYP... | various | 1A2, 2D6, 3A4 | 2D6 | 1A2, 2D6 | 3A4 | 3A4 |
| Diabetes Exacerbation | + - ++ | +++ | + | +++ | ++ | 0 |
| Hypertriglyceridemia | + - ++ | +++ | + | +++ | ++ | 0 |